CELEBRATING 25 YEARS OF JCO

Commentary

High-Dose Etoposide: From Phase I to a Component of Curative Therapy

Steven N. Wolff, John D. Hainsworth, and F. Anthony Greco

JCO Nov 20 2008: 5310–5312. First published on Oct 6 2008; 10.1200/JCO.2008.19.0892. [Full Text] [PDF] [From JCO 1983]

EDITORIALS

Bevacizumab Beyond Progression: Does This Make Sense?

Lee M. Ellis and Daniel G. Haller

JCO Nov 20 2008: 5313–5315. First published on Oct 14 2008; 10.1200/JCO.2008.17.4540. [Full Text] [PDF]

Registries That Show Efficacy: Good, but Not Good Enough

Mark N. Levine and Jim A. Julian

JCO Nov 20 2008: 5316–5319. First published on Oct 14 2008; 10.1200/JCO.2008.18.3996. [Full Text] [PDF]

Prognostic Variables for Resection of Colorectal Cancer Hepatic Metastases: An Evolving Paradigm

Anton J. Bilchik, Graeme Poston, Rene Adam, and Michael A. Choti

JCO Nov 20 2008: 5320–5321. First published on Oct 20 2008; 10.1200/JCO.2008.18.3152. [Full Text] [PDF]

Prognosis, Imatinib Dose, and Benefit of Sunitinib in GIST: Knowing the Genotype

Ian R. Judson

JCO Nov 20 2008: 5322–5325. First published on Oct 27 2008; 10.1200/JCO.2008.17.7725. [Full Text] [PDF]

ORIGINAL REPORTS
Gastrointestinal Cancer
	Bevacizumab Beyond First Progression Is Associated With Prolonged Overall Survival in Metastatic Colorectal Cancer: Results From a Large Observational Cohort Study (BRiTE)
	Axel Grothey, Mary M. Sugrue, David M. Purdie, Wei Dong, Daniel Sargent, Eric Hedrick, and Mark Kozloff
	JCO Nov 20 2008: 5326–5334. First published on Oct 14 2008; 10.1200/JCO.2008.16.3212. [Abstract] [Full Text] [PDF]
	Cetuximab Plus Irinotecan in Heavily Pretreated Metastatic Colorectal Cancer Progressing on Irinotecan: MABEL Study
	Hansjochen Wilke, Robert Glynne-Jones, Josef Thaler, Antoine Adenis, Peter Preusser, Enrique Aranda Aguilar, Matti S. Aapro, Regina Esser, Anja H. Loos, and Salvatore Siena
	JCO Nov 20 2008: 5335–5343. First published on Oct 14 2008; 10.1200/JCO.2008.16.3758. [Abstract] [Full Text] [PDF]
	Pathologic Response to Preoperative Chemotherapy: A New Outcome End Point After Resection of Hepatic Colorectal Metastases
	Dan G. Blazer, III, Yoji Kishi, Dipen M. Maru, Scott Kopetz, Yun Shin Chun, Michael J. Overman, David Fogelman, Cathy Eng, David Z. Chang, Huamin Wang, Daria Zorzi, Dario Ribero, Lee M. Ellis, Katrina Y. Glover, Robert A. Wolff, Steven A. Curley, Eddie K. Abdalla, and Jean-Nicolas Vauthey
	JCO Nov 20 2008: 5344–5351. First published on Oct 20 2008; 10.1200/JCO.2008.17.5299. [Abstract] [Full Text] [PDF]

Sarcomas
	Primary and Secondary Kinase Genotypes Correlate With the Biological and Clinical Activity of Sunitinib in Imatinib-Resistant Gastrointestinal Stromal Tumor
	Michael C. Heinrich, Robert G. Maki, Christopher L. Corless, Cristina R. Antonescu, Amy Harlow, Diana Griffith, Ajia Town, Arin Mckinley, Wen-Bin Ou, Jonathan A. Fletcher, Christopher D.M. Fletcher, Xin Huang, Darrel P. Cohen, Charles M. Baum, and George D. Demetri
	JCO Nov 20 2008: 5352–5359. First published on Oct 27 2008; 10.1200/JCO.2007.15.7461. [Abstract] [Full Text] [PDF]
	Correlation of Kinase Genotype and Clinical Outcome in the North American Intergroup Phase III Trial of Imatinib Mesylate for Treatment of Advanced Gastrointestinal Stromal Tumor: CALGB 150105 Study by Cancer and Leukemia Group B and Southwest Oncology Group
	Michael C. Heinrich, Kouros Owzar, Christopher L. Corless, Donna Hollis, Ernest C. Borden, Christopher D.M. Fletcher, Christopher W. Ryan, Margaret von Mehren, Charles D. Blanke, Cathryn Rankin, Robert S. Benjamin, Vivien H. Bramwell, George D. Demetri, Monica M. Bertagnolli, and Jonathan A. Fletcher
	JCO Nov 20 2008: 5360–5367. First published on Oct 27 2008; 10.1200/JCO.2008.17.4284. [Abstract] [Full Text] [PDF]
	Osteosarcoma in Patients Older Than 65 Years
	Alessandra Longhi, Costantino Errani, Daniel Gonzales-Arabio, Cristina Ferrari, and Mario Mercuri
	JCO Nov 20 2008: 5368–5373. First published on Sep 22 2008; 10.1200/JCO.2007.14.9104. [Abstract] [Full Text] [PDF]

Breast Cancer
	Assessment of the Accuracy of the Gail Model in Women With Atypical Hyperplasia
	V. Shane Pankratz, Lynn C. Hartmann, Amy C. Degnim, Robert A. Vierkant, Karthik Ghosh, Celine M. Vachon, Marlene H. Frost, Shaun D. Maloney, Carol Reynolds, and Judy C. Boughey
	JCO Nov 20 2008: 5374–5379. First published on Oct 14 2008; 10.1200/JCO.2007.14.8833. [Abstract] [Full Text] [PDF]
	Prevalence of Secondary Causes of Bone Loss Among Breast Cancer Patients With Osteopenia and Osteoporosis
	Pauline M. Camacho, Amit S. Dayal, Josefina L. Diaz, Fadi A. Nabhan, Monica Agarwal, John G. Norton, Patricia A. Robinson, and Kathy S. Albain
	JCO Nov 20 2008: 5380–5385. First published on Oct 27 2008; 10.1200/JCO.2008.17.7451. [Abstract] [Full Text] [PDF]
	Role of Age and Health in Treatment Recommendations for Older Adults With Breast Cancer: The Perspective of Oncologists and Primary Care Providers
	Arti Hurria, F. Lennie Wong, Doojduen Villaluna, Smita Bhatia, Cathie T. Chung, Joanne Mortimer, Sara Hurvitz, and Arash Naeim
	JCO Nov 20 2008: 5386–5392. First published on Oct 27 2008; 10.1200/JCO.2008.17.6891. [Abstract] [Full Text] [PDF]

Genetic Testing for Cancer
	Clinically Applicable Models to Characterize BRCA1 and BRCA2 Variants of Uncertain Significance
	Andrew D. Spearman, Kevin Sweet, Xiao-Ping Zhou, Jane McLennan, Fergus J. Couch, and Amanda Ewart Toland
	JCO Nov 20 2008: 5393–5400. First published on Sep 29 2008; 10.1200/JCO.2008.17.8228. [Abstract] [Full Text] [PDF]

Thoracic Oncology
	Randomized Phase II Trial Comparing Amrubicin With Topotecan in Patients With Previously Treated Small-Cell Lung Cancer: North Japan Lung Cancer Study Group Trial 0402
	Akira Inoue, Shunichi Sugawara, Koichi Yamazaki, Makoto Maemondo, Toshiro Suzuki, Kazunori Gomi, Shingo Takanashi, Chieko Inoue, Minoru Inage, Hiroshi Yokouchi, Hiroshi Watanabe, Toumei Tsukamoto, Yasuo Saijo, Osamu Ishimoto, Fumihiro Hommura, and Toshihiro Nukiwa
	JCO Nov 20 2008: 5401–5406. First published on Oct 14 2008; 10.1200/JCO.2008.18.1974. [Abstract] [Full Text] [PDF]
	Randomized Phase II Study of Vandetanib Alone or With Paclitaxel and Carboplatin as First-Line Treatment for Advanced Non–Small-Cell Lung Cancer
	John V. Heymach, Luis Paz-Ares, Filippo De Braud, Martin Sebastian, David J. Stewart, Wilfried E.E. Eberhardt, Anantbhushan A. Ranade, Graham Cohen, Jose Manuel Trigo, Alan B. Sandler, Philip D. Bonomi, Roy S. Herbst, Annetta D. Krebs, James Vasselli, and Bruce E. Johnson
	JCO Nov 20 2008: 5407–5415. First published on Oct 20 2008; 10.1200/JCO.2008.17.3138. [Abstract] [Full Text] [PDF]

Genitourinary Cancer
	Chemotherapy As an Alternative to Radiotherapy in the Treatment of Stage IIA and IIB Testicular Seminoma: A Spanish Germ Cell Cancer Group Study
	Xavier Garcia-del-Muro, Pablo Maroto, Josep Gumà, Javier Sastre, Marta López Brea, José A. Arranz, Nuria Lainez, Diego Soto de Prado, Jorge Aparicio, José M. Piulats, Xavier Pérez, and Josep R. Germá-Lluch
	JCO Nov 20 2008: 5416–5421. First published on Oct 20 2008; 10.1200/JCO.2007.15.9103. [Abstract] [Full Text] [PDF]
	Bevacizumab Plus Interferon Alfa Compared With Interferon Alfa Monotherapy in Patients With Metastatic Renal Cell Carcinoma: CALGB 90206
	Brian I. Rini, Susan Halabi, Jonathan E. Rosenberg, Walter M. Stadler, Daniel A. Vaena, San-San Ou, Laura Archer, James N. Atkins, Joel Picus, Piotr Czaykowski, Janice Dutcher, and Eric J. Small
	JCO Nov 20 2008: 5422–5428. First published on Oct 20 2008; 10.1200/JCO.2008.16.9847. [Abstract] [Full Text] [PDF]

Leukemia and Bone Marrow Transplantation
	Mutation of the Wilms’ Tumor 1 Gene Is a Poor Prognostic Factor Associated With Chemotherapy Resistance in Normal Karyotype Acute Myeloid Leukemia: The United Kingdom Medical Research Council Adult Leukaemia Working Party
	Priya Virappane, Rosemary Gale, Robert Hills, Ioannis Kakkas, Karin Summers, Jane Stevens, Christopher Allen, Claire Green, Hilmar Quentmeier, Hans Drexler, Alan Burnett, David Linch, Dominique Bonnet, T. Andrew Lister, and Jude Fitzgibbon
	JCO Nov 20 2008: 5429–5435. First published on Jun 30 2008; 10.1200/JCO.2008.16.0333. [Abstract] [Full Text] [PDF]

Melanoma
	Immunoembolization of Malignant Liver Tumors, Including Uveal Melanoma, Using Granulocyte-Macrophage Colony-Stimulating Factor
	Takami Sato, David J. Eschelman, Carin F. Gonsalves, Mizue Terai, Inna Chervoneva, Peter A. McCue, Jerry A. Shields, Carol L. Shields, Akira Yamamoto, David Berd, Michael J. Mastrangelo, and Kevin L. Sullivan
	JCO Nov 20 2008: 5436–5442. First published on Oct 6 2008; 10.1200/JCO.2008.16.0705. [Abstract] [Full Text] [PDF]

Pediatric Oncology
	PHOX2B Is a Novel and Specific Marker for Minimal Residual Disease Testing in Neuroblastoma
	Janine Stutterheim, Annemieke Gerritsen, Lily Zappeij-Kannegieter, Ilona Kleijn, Rob Dee, Lotty Hooft, Max M. van Noesel, Marc Bierings, Frank Berthold, Rogier Versteeg, Huib N. Caron, C. Ellen van der Schoot, and Godelieve A.M. Tytgat
	JCO Nov 20 2008: 5443–5449. First published on Oct 6 2008; 10.1200/JCO.2007.13.6531. [Abstract] [Full Text] [PDF]

Supportive Care and Quality of Life
	Does Age Really Matter? Recall of Information Presented to Newly Referred Patients With Cancer
	Jesse Jansen, Phyllis N. Butow, Julia C.M. van Weert, Sandra van Dulmen, Rhonda J. Devine, Thea J. Heeren, Jozien M. Bensing, and Martin H.N. Tattersall
	JCO Nov 20 2008: 5450–5457. First published on Oct 20 2008; 10.1200/JCO.2007.15.2322. [Abstract] [Full Text] [PDF]

Clinical Trials
	Evolution of the Randomized Controlled Trial in Oncology Over Three Decades
	Christopher M. Booth, David W. Cescon, Lisa Wang, Ian F. Tannock, and Monika K. Krzyzanowska
	JCO Nov 20 2008: 5458–5464. First published on Oct 27 2008; 10.1200/JCO.2008.16.5456. [Abstract] [Full Text] [PDF]

REVIEW ARTICLE
	Cancer Treatment–Induced Bone Loss in Breast and Prostate Cancer
	Fred Saad, Jonathan D. Adachi, Jacques P. Brown, Leah A. Canning, Karen A. Gelmon, Robert G. Josse, and Kathleen I. Pritchard
	JCO Nov 20 2008: 5465–5476. First published on Oct 27 2008; 10.1200/JCO.2008.18.4184. [Abstract] [Full Text] [PDF]

ART OF ONCOLOGY

Giving Permission

Steven M. Grunberg

JCO Nov 20 2008: 5477–5478. First published on Oct 27 2008; 10.1200/JCO.2008.18.7559. [Full Text] [PDF]

DIAGNOSIS IN ONCOLOGY

Positron Emission Tomography/Computed Tomography in the Diagnosis of Multifocal Primary Hepatic Lymphoma

Winnie K.S. Chan, Eric W.C. Tse, Yuen-Shan Fan, Jingbo Zhang, Yok-Lam Kwong, and Pek-Lan Khong

JCO Nov 20 2008: 5479–5480. First published on Oct 27 2008; 10.1200/JCO.2008.18.5413. [Full Text] [PDF]

Malignant Pleural Mesothelioma After Household Exposure to Asbestos

Anush V. Patel, Paul N. Bogner, Donald Klippenstein, and Nithya Ramnath

JCO Nov 20 2008: 5480–5483. First published on Oct 27 2008; 10.1200/JCO.2008.18.8268. [Full Text] [PDF]

Spontaneous Pneumocephalus Associated With Recurrent Colorectal Carcinoma

Angela Torres, Paul Y. Holoye, and Luis H. Camacho

JCO Nov 20 2008: 5483–5484. First published on Oct 27 2008; 10.1200/JCO.2008.19.4381. [Full Text] [PDF]

CORRESPONDENCE

Ramadan and Cancer

Illias Tazi

JCO Nov 20 2008: 5485. First published on Oct 20 2008; 10.1200/JCO.2008.19.7541. [Full Text] [PDF]

Interaction Between Statins and Rituximab in Non-Hodgkin's Lymphoma

Ian Rabinowitz

JCO Nov 20 2008: 5486. First published on Oct 20 2008; 10.1200/JCO.2008.19.2849. [Full Text] [PDF]

In Reply

Joseph R. Carver, Stephen J. Schuster, and John H. Glick

JCO Nov 20 2008: 5486-a. First published on Oct 20 2008; 10.1200/JCO.2008.19.3201. [Full Text] [PDF]

Quality of Reporting Primary Outcomes in Phase II Cancer Trials

Rachel P. Riechelmann, Vera Dounaevskaia, and Monika K. Krzyzanowska

JCO Nov 20 2008: 5486-b–5488. First published on Oct 27 2008; 10.1200/JCO.2008.19.7343. [Full Text] [PDF]

Emergency Use Regulatory Approval Process for Experimental Gene-Based Therapy

Gladice Wallraven, Phillip B. Maples, and John Nemunaitis

JCO Nov 20 2008: 5488–5489. First published on Oct 20 2008; 10.1200/JCO.2008.19.3334. [Full Text] [PDF]

Evidence for Linkage Disequilibrium Between FcRIIIa-V158F and FcRIIa-H131R Polymorphisms in White Patients, and for an FcRIIIa-Restricted Influence on the Response to Therapeutic Antibodies

Julien Lejeune, Gilles Thibault, David Ternant, Guillaume Cartron, Hervé Watier, and Marc Ohresser

JCO Nov 20 2008: 5489–5491. First published on Oct 27 2008; 10.1200/JCO.2008.19.4118. [Full Text] [PDF]

In Reply

Antonino Musolino, Nadia Naldi, Beatrice Bortesi, Debora Pezzuolo, Marzia Capelletti, Gabriele Missale, Diletta Laccabue, Alessandro Zerbini, Roberta Camisa, Giancarlo Bisagni, Tauro Maria Neri, and Andrea Ardizzoni

JCO Nov 20 2008: 5491–5492. First published on Oct 27 2008; 10.1200/JCO.2008.19.4696. [Full Text] [PDF]

ERRATA

ERRATUM

JCO Nov 20 2008: 5493. [Full Text] [PDF]

ERRATUM

JCO Nov 20 2008: 5493-a. [Full Text] [PDF]

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