EDITORIAL

Role for Drug Transporters Beyond Tumor Resistance: Hepatic Functional Imaging and Genotyping of Multidrug Resistance Transporters for the Prediction of Irinotecan Toxicity

Deanna L. Kroetz

JCO Sep 10 2006: 4225–4227. First published on Aug 8 2006; 10.1200/JCO.2006.07.2355. [Full Text] [PDF]

ORIGINAL REPORTS
Phase I and Clinical Pharmacology
	Relationship of Hepatic Functional Imaging to Irinotecan Pharmacokinetics and Genetic Parameters of Drug Elimination
	Michael Michael, Mick Thompson, Rod J. Hicks, Paul L. Mitchell, Andrew Ellis, Alvin D. Milner, Julia Di Iulio, Andrew M. Scott, Volker Gurtler, Janelle M. Hoskins, Stephen J. Clarke, Niall C. Tebbut, Kian Foo, Michael Jefford, and John R. Zalcberg
	JCO Sep 10 2006: 4228–4235. First published on Aug 8 2006; 10.1200/JCO.2005.04.8496. [Abstract] [Full Text] [PDF]

Breast Cancer
	Pharmacogenomic Predictor of Sensitivity to Preoperative Chemotherapy With Paclitaxel and Fluorouracil, Doxorubicin, and Cyclophosphamide in Breast Cancer
	Kenneth R. Hess, Keith Anderson, W. Fraser Symmans, Vicente Valero, Nuhad Ibrahim, Jaime A. Mejia, Daniel Booser, Richard L. Theriault, Aman U. Buzdar, Peter J. Dempsey, Roman Rouzier, Nour Sneige, Jeffrey S. Ross, Tatiana Vidaurre, Henry L. Gómez, Gabriel N. Hortobagyi, and Lajos Pusztai
	JCO Sep 10 2006: 4236–4244. First published on Aug 8 2006; 10.1200/JCO.2006.05.6861. [Abstract] [Full Text] [PDF]
	Increased Expression of Urokinase-Type Plasminogen Activator mRNA Determines Adverse Prognosis in ErbB2-Positive Primary Breast Cancer
	Patrick Urban, Vincent Vuaroqueaux, Martin Labuhn, Mauro Delorenzi, Pratyaksha Wirapati, Edward Wight, Hans-Jörg Senn, Christopher Benz, Urs Eppenberger, and Serenella Eppenberger-Castori
	JCO Sep 10 2006: 4245–4253. [Abstract] [Full Text] [PDF]
	T-Cell Immunity to the Folate Receptor Alpha Is Prevalent in Women With Breast or Ovarian Cancer
	Keith L. Knutson, Christopher J. Krco, Courtney L. Erskine, Karin Goodman, Linda E. Kelemen, Peter J. Wettstein, Philip S. Low, Lynn C. Hartmann, and Kimberly R. Kalli
	JCO Sep 10 2006: 4254–4261. First published on Aug 14 2006; 10.1200/JCO.2006.05.9311. [Abstract] [Full Text] [PDF]
	Detection of Aberrant Methylation of Four Genes in Plasma DNA for the Detection of Breast Cancer
	Mohammad O. Hoque, Qinghua Feng, Papa Toure, Amadou Dem, Cathy W. Critchlow, Stephen E. Hawes, Troy Wood, Carmen Jeronimo, Eli Rosenbaum, Joshua Stern, Mujun Yu, Barry Trink, Nancy B. Kiviat, and David Sidransky
	JCO Sep 10 2006: 4262–4269. First published on Aug 14 2006; 10.1200/JCO.2005.01.3516. [Abstract] [Full Text] [PDF]
	Prediction of Breast Tumor Progression by Integrity of Free Circulating DNA in Serum
	Naoyuki Umetani, Armando E. Giuliano, Suzanne H. Hiramatsu, Farin Amersi, Taku Nakagawa, Silvana Martino, and Dave S.B. Hoon
	JCO Sep 10 2006: 4270–4276. [Abstract] [Full Text] [PDF]

Gastrointestinal Cancer
	Surgical Mortality in Patients With Esophageal Cancer: Development and Validation of a Simple Risk Score
	Ewout W. Steyerberg, Bridget A. Neville, Linetta B. Koppert, Valery E.P.P. Lemmens, Hugo W. Tilanus, Jan-Willem W. Coebergh, Jane C. Weeks, and Craig C. Earle
	JCO Sep 10 2006: 4277–4284. [Abstract] [Full Text] [PDF]
	Genotype-Phenotype Comparison of German MLH1 and MSH2 Mutation Carriers Clinically Affected With Lynch Syndrome: A Report by the German HNPCC Consortium
	Timm Goecke, Karsten Schulmann, Christoph Engel, Elke Holinski-Feder, Constanze Pagenstecher, Hans K. Schackert, Matthias Kloor, Erdmute Kunstmann, Holger Vogelsang, Gisela Keller, Wolfgang Dietmaier, Elisabeth Mangold, Nicolaus Friedrichs, Peter Propping, Stefan Krüger, Johannes Gebert, Wolff Schmiegel, Josef Rueschoff, Markus Loeffler, and Gabriela Moeslein
	JCO Sep 10 2006: 4285–4292. First published on Aug 14 2006; 10.1200/JCO.2005.03.7333. [Abstract] [Full Text] [PDF]
	Phase II Study of Sorafenib in Patients With Advanced Hepatocellular Carcinoma
	Ghassan K. Abou-Alfa, Lawrence Schwartz, Sergio Ricci, Dino Amadori, Armando Santoro, Arie Figer, Jacques De Greve, Jean-Yves Douillard, Chetan Lathia, Brian Schwartz, Ian Taylor, Marius Moscovici, and Leonard B. Saltz
	JCO Sep 10 2006: 4293–4300. First published on Aug 14 2006; 10.1200/JCO.2005.01.3441. [Abstract] [Full Text] [PDF]
	Lactate Dehydrogenase 5 Expression in Operable Colorectal Cancer: Strong Association With Survival and Activated Vascular Endothelial Growth Factor Pathway—A Report of the Tumour Angiogenesis Research Group
	Michael I. Koukourakis, Alexandra Giatromanolaki, Efthimios Sivridis, Kevin C. Gatter, and Adrian L. Harris
	JCO Sep 10 2006: 4301–4308. First published on Aug 8 2006; 10.1200/JCO.2006.05.9501. [Abstract] [Full Text] [PDF]
	Pharmacodynamic Studies of Gefitinib in Tumor Biopsy Specimens From Patients With Advanced Gastric Carcinoma
	Federico Rojo, Josep Tabernero, Joan Albanell, Eric Van Cutsem, Atsushi Ohtsu, Toshihiko Doi, Wasaburo Koizumi, Kuniaki Shirao, Hiroya Takiuchi, S. Ramon Cajal, and José Baselga
	JCO Sep 10 2006: 4309–4316. [Abstract] [Full Text] [PDF]

Gynecologic Cancer
	ErbB-3 Predicts Survival in Ovarian Cancer
	Berno Tanner, Dirk Hasenclever, Katja Stern, Wiebke Schormann, Martin Bezler, Matthias Hermes, Marc Brulport, Alexander Bauer, Ilka B. Schiffer, Susanne Gebhard, Markus Schmidt, Eric Steiner, Jalid Sehouli, Jeanett Edelmann, Jürgen Läuter, Rüdiger Lessig, K. Krishnamurthi, Axel Ullrich, and Jan Georg Hengstler
	JCO Sep 10 2006: 4317–4323. First published on Aug 8 2006; 10.1200/JCO.2005.04.8397. [Abstract] [Full Text] [PDF]
	Clinical Activity of Pertuzumab (rhuMAb 2C4), a HER Dimerization Inhibitor, in Advanced Ovarian Cancer: Potential Predictive Relationship With Tumor HER2 Activation Status
	Michael S. Gordon, Daniela Matei, Carol Aghajanian, Ursula A. Matulonis, Molly Brewer, Gini F. Fleming, John D. Hainsworth, Agustin A. Garcia, Mark D. Pegram, Russell J. Schilder, David E. Cohn, Lynda Roman, Mika K. Derynck, Kimmie Ng, Benjamin Lyons, David E. Allison, David A. Eberhard, Thinh Q. Pham, Randall C. Dere, and Beth Y. Karlan
	JCO Sep 10 2006: 4324–4332. First published on Aug 8 2006; 10.1200/JCO.2005.05.4221. [Abstract] [Full Text] [PDF] [Publisher's Note]

Head and Neck Cancer
	DNA-Repair Gene Polymorphisms Predict Favorable Clinical Outcome Among Patients With Advanced Squamous Cell Carcinoma of the Head and Neck Treated With Cisplatin-Based Induction Chemotherapy
	Miguel Quintela-Fandino, Ricardo Hitt, Pedro P. Medina, Soledad Gamarra, Luis Manso, Hernan Cortes-Funes, and Montserrat Sanchez-Cespedes
	JCO Sep 10 2006: 4333–4339. First published on Aug 8 2006; 10.1200/JCO.2006.05.8768. [Abstract] [Full Text] [PDF]

Melanoma
	Somatic Activation of KIT in Distinct Subtypes of Melanoma
	John A. Curtin, Klaus Busam, Daniel Pinkel, and Boris C. Bastian
	JCO Sep 10 2006: 4340–4346. First published on Aug 14 2006; 10.1200/JCO.2006.06.2984. [Abstract] [Full Text] [PDF]

REVIEW ARTICLE
	Prognostic Factors in Adenocarcinoma of the Esophagus or Gastroesophageal Junction
	Sjoerd M. Lagarde, Fiebo J.W. ten Kate, Johannes B. Reitsma, Olivier R.C. Busch, and J. Jan B. van Lanschot
	JCO Sep 10 2006: 4347–4355. [Abstract] [Full Text] [PDF]

BIOLOGY OF NEOPLASIA
	Is There a Role for SV40 in Human Cancer?
	Danielle L. Poulin and James A. DeCaprio
	JCO Sep 10 2006: 4356–4365. [Abstract] [Full Text] [PDF]

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