OVERVIEW

Making Bad Cells Go Good: The Promise of Epigenetic Therapy

Edward A. Sausville and Michael A. Carducci

JCO Jun 10 2005: 3875–3876. [Full Text] [PDF]

ORIGINAL REPORTS
Molecular Oncology
	TWIST2 Demonstrates Differential Methylation in Immunoglobulin Variable Heavy Chain Mutated and Unmutated Chronic Lymphocytic Leukemia
	Aparna Raval, David M. Lucas, Jennifer J. Matkovic, Kristi L. Bennett, Sandya Liyanarachchi, Donn C. Young, Laura Rassenti, Thomas J. Kipps, Michael R. Grever, John C. Byrd, and Christoph Plass
	JCO Jun 10 2005: 3877–3885. First published on Apr 4 2005; 10.1200/JCO.2005.02.196. [Abstract] [Full Text] [PDF]
	Epigenetic Profiling of Cutaneous T-Cell Lymphoma: Promoter Hypermethylation of Multiple Tumor Suppressor Genes Including BCL7a, PTPRG, and p73
	Remco van Doorn, Willem H. Zoutman, Remco Dijkman, Renee X. de Menezes, Suzan Commandeur, Aat A. Mulder, Pieter A. van der Velden, Maarten H. Vermeer, Rein Willemze, Pearlly S. Yan, Tim H. Huang, and Cornelis P. Tensen
	JCO Jun 10 2005: 3886–3896. First published on May 16 2005; 10.1200/JCO.2005.11.353. [Abstract] [Full Text] [PDF]

Phase I and Clinical Pharmacology
	Evaluation of a 7-Day Continuous Intravenous Infusion of Decitabine: Inhibition of Promoter-Specific and Global Genomic DNA Methylation
	Wolfram E. Samlowski, Sancy A. Leachman, Mark Wade, Pamela Cassidy, Patricia Porter-Gill, Leslie Busby, Richard Wheeler, Kenneth Boucher, Frank Fitzpatrick, David A. Jones, and Adam R. Karpf
	JCO Jun 10 2005: 3897–3905. First published on Mar 7 2005; 10.1200/JCO.2005.06.118. [Abstract] [Full Text] [PDF] [Publisher's Note]
	Pharmacokinetics of 5-Azacitidine Administered With Phenylbutyrate in Patients With Refractory Solid Tumors or Hematologic Malignancies
	Michelle A. Rudek, Ming Zhao, Ping He, Carol Hartke, Jill Gilbert, Steven D. Gore, Michael A. Carducci, and Sharyn D. Baker
	JCO Jun 10 2005: 3906–3911. First published on Apr 25 2005; 10.1200/JCO.2005.07.450. [Abstract] [Full Text] [PDF]
	Phase I and Pharmacokinetic Study of MS-275, a Histone Deacetylase Inhibitor, in Patients With Advanced and Refractory Solid Tumors or Lymphoma
	Qin C. Ryan, Donna Headlee, Milin Acharya, Alex Sparreboom, Jane B. Trepel, Joseph Ye, William D. Figg, Kyunghwa Hwang, Eun Joo Chung, Anthony Murgo, Giovanni Melillo, Yusri Elsayed, Manish Monga, Mikhail Kalnitskiy, James Zwiebel, and Edward A. Sausville
	JCO Jun 10 2005: 3912–3922. First published on Apr 25 2005; 10.1200/JCO.2005.02.188. [Abstract] [Full Text] [PDF]
	Phase I Study of an Oral Histone Deacetylase Inhibitor, Suberoylanilide Hydroxamic Acid, in Patients With Advanced Cancer
	William Kevin Kelly, Owen A. O'Connor, Lee M. Krug, Judy H. Chiao, Mark Heaney, Tracy Curley, Barbara MacGregore-Cortelli, William Tong, J. Paul Secrist, Lawrence Schwartz, Stacy Richardson, Elaina Chu, Semra Olgac, Paul A. Marks, Howard Scher, and Victoria M. Richon
	JCO Jun 10 2005: 3923–3931. First published on May 16 2005; 10.1200/JCO.2005.14.167. [Abstract] [Full Text] [PDF]

Hematologic Malignancies
	Protein Expression of a Triad of Frequently Methylated Genes, p73, p57Kip2, and p15, Has Prognostic Value in Adult Acute Lymphocytic Leukemia Independently of Its Methylation Status
	Carlos Bueso-Ramos, Yunling Xu, Timothy J. McDonnell, Shawn Brisbay, Sherry Pierce, Hagop Kantarjian, Gary Rosner, and Guillermo Garcia-Manero
	JCO Jun 10 2005: 3932–3939. First published on Apr 25 2005; 10.1200/JCO.2005.02.998. [Abstract] [Full Text] [PDF]
	Inactivation of the Lamin A/C Gene by CpG Island Promoter Hypermethylation in Hematologic Malignancies, and Its Association With Poor Survival in Nodal Diffuse Large B-Cell Lymphoma
	Ruben Agrelo, Fernando Setien, Jesus Espada, Maria Jesus Artiga, Maria Rodriguez, Alberto Pérez-Rosado, Abel Sanchez-Aguilera, Mario F. Fraga, Miguel Angel Piris, and Manel Esteller
	JCO Jun 10 2005: 3940–3947. First published on May 2 2005; 10.1200/JCO.2005.11.650. [Abstract] [Full Text] [PDF]
	Phase II Study of Low-Dose Decitabine in Patients With Chronic Myelogenous Leukemia Resistant to Imatinib Mesylate
	Jean-Pierre J. Issa, Vazganush Gharibyan, Jorge Cortes, Jaroslav Jelinek, Gail Morris, Srdan Verstovsek, Moshe Talpaz, Guillermo Garcia-Manero, and Hagop M. Kantarjian
	JCO Jun 10 2005: 3948–3956. First published on May 9 2005; 10.1200/JCO.2005.11.981. [Abstract] [Full Text] [PDF]

REVIEW ARTICLES
	The Theoretical Basis of Transcriptional Therapy of Cancer: Can It Be Put Into Practice?
	Ari M. Melnick, Kerin Adelson, and Jonathan D. Licht
	JCO Jun 10 2005: 3957–3970. First published on May 2 2005; 10.1200/JCO.2005.14.498. [Abstract] [Full Text] [PDF]
	Epigenetic and Chromatin Modifiers As Targeted Therapy of Hematologic Malignancies
	Kapil N. Bhalla
	JCO Jun 10 2005: 3971–3993. First published on May 16 2005; 10.1200/JCO.2005.16.600. [Abstract] [Full Text] [PDF]

GLOSSARY

Glossary

JCO Jun 10 2005: 3994–4002. [PDF]

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