EDITORIALS

Breast Cancer Screening for High-Risk Women: Too Little, Too Late?

Katrina Armstrong and Barbara L. Weber

JCO Feb 15 2001: 919–920. [Full Text] [PDF]

Intraperitoneal Therapy for Ovarian Cancer: A Sacrifice Bunt

William P. McGuire

JCO Feb 15 2001: 921–923. [Full Text] [PDF]

ORIGINAL REPORTS
Breast Cancer
	Effectiveness of Breast Cancer Surveillance in BRCA1/2 Gene Mutation Carriers and Women With High Familial Risk
	C.T.M. Brekelmans, C. Seynaeve, C.C.M. Bartels, M.M.A. Tilanus-Linthorst, E.J. Meijers-Heijboer, C.M.G. Crepin, A.N. van Geel, M. Menke, L.C. Verhoog, A. van den Ouweland, I.M. Obdeijn, and J.G.M. Klijn
	JCO Feb 15 2001: 924–930. [Abstract] [Full Text] [PDF]
	Tamoxifen and Chemotherapy for Axillary Node-Negative, Estrogen Receptor–Negative Breast Cancer: Findings From National Surgical Adjuvant Breast and Bowel Project B-23
	Bernard Fisher, Stewart Anderson, Elizabeth Tan-Chiu, Norman Wolmark, D. Lawrence Wickerham, Edwin R. Fisher, Nikolay V. Dimitrov, James N. Atkins, Neil Abramson, Sofia Merajver, Edward H. Romond, Carl G. Kardinal, Henry R. Shibata, Richard G. Margolese, and William B. Farrar
	JCO Feb 15 2001: 931–942. [Abstract] [Full Text] [PDF]
	Dose-Intensive Epirubicin-Based Chemotherapy Is Superior to an Intensive Intravenous Cyclophosphamide, Methotrexate, and Fluorouracil Regimen in Metastatic Breast Cancer: A Randomized Multinational Study
	Stephen P. Ackland, Antonio Anton, George Peter Breitbach, Elena Colajori, Jennifer M. Tursi, Carlos Delfino, Anna Efremidis, Adnan Ezzat, Alberto Fittipaldo, Kristo Kolaric, Massimo Lopez, and Donatella Viaro
	JCO Feb 15 2001: 943–953. [Abstract] [Full Text] [PDF]
	Influences on Oncologists’ Adoption of New Agents in Adjuvant Chemotherapy of Breast Cancer
	Gina M. Buban, Brian K. Link, and William R. Doucette
	JCO Feb 15 2001: 954–959. [Abstract] [Full Text] [PDF]
	Simultaneous Immunohistochemical Detection of Tumor Cells in Lymph Nodes and Bone Marrow Aspirates in Breast Cancer and Its Correlation With Other Prognostic Factors
	Bernd Gerber, Annette Krause, Heiner Müller, Dagmar Richter, Toralf Reimer, Josef Makovitzky, Christina Herrnring, Udo Jeschke, Günther Kundt, and Klaus Friese
	JCO Feb 15 2001: 960–971. [Abstract] [Full Text] [PDF]
	Understanding the Utility of Adjuvant Systemic Therapy for Primary Breast Cancer
	Charles L. Loprinzi and Stephan D. Thomé
	JCO Feb 15 2001: 972–979. [Abstract] [Full Text] [PDF]
	Computer Program to Assist in Making Decisions About Adjuvant Therapy for Women With Early Breast Cancer
	Peter M. Ravdin, Laura A. Siminoff, Greg J. Davis, Mary Beth Mercer, Joan Hewlett, Nancy Gerson, and Helen L. Parker
	JCO Feb 15 2001: 980–991. [Abstract] [Full Text] [PDF]
	BAG-1: A Novel Biomarker Predicting Long-Term Survival in Early-Stage Breast Cancer
	Bruce C. Turner, Stanislaw Krajewski, Maryla Krajewska, Shinichi Takayama, Andrew A. Gumbs, Darryl Carter, Timothy R. Rebbeck, Bruce G. Haffty, and John C. Reed
	JCO Feb 15 2001: 992–1000. [Abstract] [Full Text] [PDF]

Gynecologic Cancer
	Phase III Trial of Standard-Dose Intravenous Cisplatin Plus Paclitaxel Versus Moderately High-Dose Carboplatin Followed by Intravenous Paclitaxel and Intraperitoneal Cisplatin in Small-Volume Stage III Ovarian Carcinoma: An Intergroup Study of the Gynecologic Oncology Group, Southwestern Oncology Group, and Eastern Cooperative Oncology Group
	Maurie Markman, Brian N. Bundy, David S. Alberts, Jeffrey M. Fowler, Daniel L. Clark-Pearson, Linda F. Carson, Scott Wadler, and Joshua Sickel
	JCO Feb 15 2001: 1001–1007. [Abstract] [Full Text] [PDF]
	Microsatellite Instability Is an Independent Indicator of Recurrence in Sporadic Stage I-II Endometrial Adenocarcinoma
	Silvia Fiumicino, Alfredo Ercoli, Gabriella Ferrandina, Patricia Hess, Giuseppina Raspaglio, Maurizio Genuardi, Valentina Rovella, Alfonso Bellacosa, Lucia Cicchillitti, Salvatore Mancuso, Margherita Bignami, and Giovanni Scambia
	JCO Feb 15 2001: 1008–1014. [Abstract] [Full Text] [PDF]
	Survival and Reproductive Function After Treatment of Malignant Germ Cell Ovarian Tumors
	Gerardo Zanetta, Cristina Bonazzi, Maria Grazia Cantù, Anna Locatelli, Giorgio Bratina, and Costantino Mangioni
	JCO Feb 15 2001: 1015–1020. [Abstract] [Full Text] [PDF]
	Phase I Trial of Escalating Doses of Paclitaxel Combined With Fixed Doses of Cisplatin and Doxorubicin in Advanced Endometrial Cancer and Other Gynecologic Malignancies: A Gynecologic Oncology Group Study
	Gini F. Fleming, Jeffrey M. Fowler, Steven E. Waggoner, Larry J. Copeland, Benjamin E. Greer, Ira Horowitz, Gregory Sutton, Russell J. Schilder, Paula M. Fracasso, Harrison G. Ball, and William P. McGuire, III
	JCO Feb 15 2001: 1021–1029. [Abstract] [Full Text] [PDF]

Genitourinary Cancer
	Prediction of Response to Salvage Radiation Therapy in Patients With Prostate Cancer Recurrence After Radical Prostatectomy
	Angelos K. Leventis, Shahrokh F. Shariat, Michael W. Kattan, E. Brian Butler, Thomas M. Wheeler, and Kevin M. Slawin
	JCO Feb 15 2001: 1030–1039. [Abstract] [Full Text] [PDF]

Pediatric Oncology
	Improved Response With Higher Corticosteroid Dose in Children With Acute Lymphoblastic Leukemia
	Cindy L. Schwartz, E. Brad Thompson, Richard D. Gelber, Mary L. Young, David Chilton, Harvey J. Cohen, and Stephen E. Sallan
	JCO Feb 15 2001: 1040–1046. [Abstract] [Full Text] [PDF]
	Treatment and Outcome of 83 Children With Intraspinal Neuroblastoma: The Pediatric Oncology Group Experience
	Howard M. Katzenstein, Paul M. Kent, Wendy B. London, and Susan L. Cohn
	JCO Feb 15 2001: 1047–1055. [Abstract] [Full Text] [PDF]

Lung Cancer
	Second Cancers Occurring in Patients With Early Stage Non–Small-Cell Lung Cancer Treated With Chest Radiation Therapy Alone
	Branislav Jeremic, Yuta Shibamoto, Ljubisa Acimovic, Nebojsa Nikolic, Aleksandar Dagovic, Jasna Aleksandrovic, and Gordana Radosavljevic-Asic
	JCO Feb 15 2001: 1056–1063. [Abstract] [Full Text] [PDF]
	Effectiveness of Chemotherapy for Advanced Lung Cancer in the Elderly: Instrumental Variable and Propensity Analysis
	Craig C. Earle, Jerry S. Tsai, Richard D. Gelber, Milton C. Weinstein, Peter J. Neumann, and Jane C. Weeks
	JCO Feb 15 2001: 1064–1070. [Abstract] [Full Text] [PDF]
	Phase II Trial of Paclitaxel Plus Gemcitabine in Patients With Locally Advanced or Metastatic Non–Small-Cell Lung Cancer
	Dolores Isla, Rafael Rosell, José J. Sánchez, Alfredo Carrato, Enriqueta Felip, Carlos Camps, Angel Artal, José Luis González-Larriba, Pilar Azagra, Vicente Alberola, Cristina Martin, and Bartomeu Massutí
	JCO Feb 15 2001: 1071–1077. [Abstract] [Full Text] [PDF]
	Phase I Trial of the Combination of Irinotecan, Paclitaxel, and Carboplatin in Patients With Advanced Non–Small-Cell Lung Cancer
	Mark A. Socinski, Alan B. Sandler, Langdon L. Miller, Paula K. Locker, Cristy K. Hanover, Gary L. Elfring, Valerie K. Israel, Nicoletta Pirotta, and Ronald B. Natale
	JCO Feb 15 2001: 1078–1087. [Abstract] [Full Text] [PDF]

Head and Neck Cancer
	Phase III Comparison of High-Dose Paclitaxel + Cisplatin + Granulocyte Colony-Stimulating Factor Versus Low-Dose Paclitaxel + Cisplatin in Advanced Head and Neck Cancer: Eastern Cooperative Oncology Group Study E1393
	Arlene A. Forastiere, Traci Leong, Eric Rowinsky, Barbara A. Murphy, Daniel R. Vlock, Ronald C. DeConti, and George L. Adams
	JCO Feb 15 2001: 1088–1095. [Abstract] [Full Text] [PDF]
	Multicenter Phase I-II Trial of Docetaxel, Cisplatin, and Fluorouracil Induction Chemotherapy for Patients With Locally Advanced Squamous Cell Cancer of the Head and Neck
	Marshall R. Posner, Bonnie Glisson, Gary Frenette, Muhyi Al-Sarraf, A. Dimitrios Colevas, Charles M. Norris, Jeffery D. Seroskie, Dong M. Shin, Robert Olivares, and Carlos A. Garay
	JCO Feb 15 2001: 1096–1104. [Abstract] [Full Text] [PDF]
	Accelerated Concomitant Boost Radiotherapy and Chemotherapy for Advanced Nasopharyngeal Carcinoma
	Suzanne L. Wolden, Michael J. Zelefsky, Dennis H. Kraus, Kenneth E. Rosenzweig, Lanceford M. Chong, Ashok R. Shaha, Haige Zhang, Louis B. Harrison, Jatin P. Shah, and David G. Pfister
	JCO Feb 15 2001: 1105–1110. [Abstract] [Full Text] [PDF]

Central Nervous System
	Phase I Study of Topotecan Plus Cranial Radiation for Glioblastoma Multiforme: Results of Radiation Therapy Oncology Group Trial 9507
	Barbara J. Fisher, C. Scott, D. R. Macdonald, C. Coughlin, and W. J. Curran
	JCO Feb 15 2001: 1111–1117. [Abstract] [Full Text] [PDF]

Gastrointestinal Cancer
	Expression of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Human Pancreatic Adenocarcinomas: Clinicopathologic and Prognostic Significance of Matrilysin Expression
	Hiroyuki Yamamoto, Fumio Itoh, Shouhei Iku, Yasushi Adachi, Hiroshi Fukushima, Shigeru Sasaki, Mitsuhiro Mukaiya, Koichi Hirata, and Kohzoh Imai
	JCO Feb 15 2001: 1118–1127. [Abstract] [Full Text] [PDF]
	Molecular Staging of Early Colon Cancer on the Basis of Sentinel Node Analysis: A Multicenter Phase II Trial
	Anton J. Bilchik, Sukamal Saha, David Wiese, James A. Stonecypher, Thomas F. Wood, Stuart Sostrin, Roderick R. Turner, He-Jing Wang, Donald L. Morton, and Dave S.B. Hoon
	JCO Feb 15 2001: 1128–1136. [Abstract] [Full Text] [PDF]

Cancer Related Complications
	Incidence, Cost, and Outcomes of Bleeding and Chemotherapy Dose Modification Among Solid Tumor Patients With Chemotherapy-Induced Thrombocytopenia
	Linda S. Elting, Edward B. Rubenstein, Charles G. Martin, Danna Kurtin, Saul Rodriguez, Esa Laiho, Krishnakumari Kanesan, Scott B. Cantor, and Robert S. Benjamin
	JCO Feb 15 2001: 1137–1146. [Abstract] [Full Text] [PDF]
	Perspectives on Comorbidity and Cancer in Older Patients: Approaches to Expand the Knowledge Base
	Rosemary Yancik, Patricia A. Ganz, Claudette G. Varricchio, and Barbara Conley
	JCO Feb 15 2001: 1147–1151. [Abstract] [Full Text] [PDF]

Hematologic Malignancies
	CD6+ Donor Marrow T-Cell Depletion as the Sole Form of Graft-Versus-Host Disease Prophylaxis in Patients Undergoing Allogeneic Bone Marrow Transplant From Unrelated Donors
	Robert J. Soiffer, Edie Weller, Edwin P. Alyea, Peter Mauch, Iain L. Webb, David C. Fisher, Arnold S. Freedman, Robert L. Schlossman, John Gribben, Stephanie Lee, Kenneth C. Anderson, Karen Marcus, Richard M. Stone, Joseph H. Antin, and Jerome Ritz
	JCO Feb 15 2001: 1152–1159. [Abstract] [Full Text] [PDF]

Phase I and Clinical Pharmacology
	Coadministration of Cyclosporine Strongly Enhances the Oral Bioavailability of Docetaxel
	Mirte M. Malingré, Dick J. Richel, Jos H. Beijnen, Hilde Rosing, Franciska J. Koopman, Wim W. Ten Bokkel Huinink, Margaret E. Schot, and Jan H.M. Schellens
	JCO Feb 15 2001: 1160–1166. [Abstract] [Full Text] [PDF]
	Phase I and Pharmacokinetic Study of the Oral Farnesyl Transferase Inhibitor SCH 66336 Given Twice Daily to Patients With Advanced Solid Tumors
	Ferry A.L.M. Eskens, Ahmad Awada, David L. Cutler, Maja J.A. de Jonge, Gré P.M. Luyten, Marije N. Faber, Paul Statkevich, Alex Sparreboom, Jaap Verweij, Axel-R. Hanauske, and Martine Piccart
	JCO Feb 15 2001: 1167–1175. [Abstract] [Full Text] [PDF]
	Phase I Trial of Multiple Cycles of High-Dose Carboplatin, Paclitaxel, and Topotecan With Peripheral-Blood Stem-Cell Support as Front-Line Therapy
	Russell J. Schilder, James M. Gallo, Michael M. Millenson, Michael A. Bookman, Louis M. Weiner, André Rogatko, Barbara Rogers, Kristin Padavic-Shallers, Matthew Boente, Norman Rosenblum, Andrea L. Adams, Suzanne Ciccotto, and Robert F. Ozols
	JCO Feb 15 2001: 1183–1194. [Abstract] [Full Text] [PDF]

Melanoma
	Tumor-Associated Antigen TA90 Immune Complex Assay Predicts Recurrence and Survival After Surgical Treatment of Stage I-III Melanoma
	Mark C. Kelley, Rishab K. Gupta, Eddy C. Hsueh, Reynold Yee, Stacey Stern, and Donald L. Morton
	JCO Feb 15 2001: 1176–1182. [Abstract] [Full Text] [PDF]

REVIEW ARTICLES
	Redefining the Target: Chemotherapeutics as Antiangiogenics
	Kathy D. Miller, Christopher J. Sweeney, and George W. Sledge, Jr
	JCO Feb 15 2001: 1195–1206. [Abstract] [Full Text] [PDF]
	Clinical Implications of Circulating Angiogenic Factors in Cancer Patients
	Ronnie Tung-Ping Poon, Sheung-Tat Fan, and John Wong
	JCO Feb 15 2001: 1207–1225. [Abstract] [Full Text] [PDF]

SPECIAL DEPARTMENTS

CORRESPONDENCE

Adjuvant Therapy of Melanoma: At What Cost?

Lynn E. Spitler and John M. Kirkwood

JCO Feb 15 2001: 1226–1228. [Full Text] [PDF]

Subclassification of N2 Non–Small-Cell Lung Cancer

Frederic W. Grannis, Jr, F. Andre, T. Le Chevalier, and D. Grunenwald

JCO Feb 15 2001: 1228–1229. [Full Text]

Gemcitabine and Cisplatin for Advanced, Metastatic Bladder Cancer

Martin H. Cohen, Mark Rothmann, Hans von der Maase, and Anna Marie Hayden

JCO Feb 15 2001: 1229–1231. [Full Text]

Secondary Leukemia After Adjuvant Chemotherapy for Breast Cancer

Richard G. Ghalie, Donald E. Goodkin, C. Bonithon-Kopp, C. Milan, G. Chaplain, C. Sgro, and P.M. Carli

JCO Feb 15 2001: 1231–1233. [Full Text]

Phase III Randomized Trial of Amifostine as a Radioprotector in Head and Neck Cancer

Bhadrasain Vikram and David M. Brizel

JCO Feb 15 2001: 1233–1234. [Full Text]

Staging of Breast Cancer: It Is Time to Break With Tradition and Initiate the Evidence-Based-Medicine Age

Alberto Ravaioli, Davide Tassinari, Ilaria Panzini, Carlo Milandri, and Dino Amadori

JCO Feb 15 2001: 1234. [Full Text]

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