EDITORIALS

Anthracycline Adjuvant Chemotherapy: How Much Is Enough?

Mark N. Levine and Andrea Eisen

JCO Feb 1 2001: 599–601. [Full Text] [PDF]

ORIGINAL REPORTS
Breast Cancer
	Benefit of a High-Dose Epirubicin Regimen in Adjuvant Chemotherapy for Node-Positive Breast Cancer Patients With Poor Prognostic Factors: 5-Year Follow-Up Results of French Adjuvant Study Group 05 Randomized Trial
	JCO Feb 1 2001: 602–611. [Abstract] [Full Text] [PDF]
	Intensification of Adjuvant Chemotherapy: 5-Year Results of a Randomized Trial Comparing Conventional Doxorubicin and Cyclophosphamide With High-Dose Mitoxantrone and Cyclophosphamide With Filgrastim in Operable Breast Cancer With 10 or More Involved Axillary Nodes
	Pierre Fumoleau, Franck Chauvin, Moïse Namer, Roland Bugat, Michèle Tubiana-Hulin, Jean Paul Guastalla, Thierry Delozier, Pierre Kerbrat, Yves Devaux, Jacques Bonneterre, Annie Filleul, and Michel Clavel
	JCO Feb 1 2001: 612–620. [Abstract] [Full Text] [PDF]
	Treatment of Advanced Breast Cancer with Vinorelbine and Docetaxel With or Without Human Granulocyte Colony-Stimulating Factor
	Gabriela V. Kornek, Herbert Ulrich-Pur, Melitta Penz, Karin Haider;, Werner Kwasny, Dieter Depisch, Erwin Kovats, Fritz Lang, Bruno Schneeweiss, and Werner Scheithauer
	JCO Feb 1 2001: 621–627. [Abstract] [Full Text] [PDF]
	Long-Term Results of Combined-Modality Therapy for Locally Advanced Breast Cancer With Ipsilateral Supraclavicular Metastases: The University of Texas M.D. Anderson Cancer Center Experience
	Rogelio A. Brito, Vicente Valero, Aman U. Buzdar, Daniel J. Booser, Frederick Ames, Eric Strom, Merrick Ross, Richard L. Theriault, Debra Frye, Shu-Wan Kau, Lina Asmar, Marsha McNeese, S. Eva Singletary, and Gabriel N. Hortobagyi
	JCO Feb 1 2001: 628–633. [Abstract] [Full Text] [PDF]
	Pilot Trial of Interleukin-2 With Granulocyte Colony-Stimulating Factor for the Mobilization of Progenitor Cells in Advanced Breast Cancer Patients Undergoing High-Dose Chemotherapy: Expansion of Immune Effectors Within the Stem-Cell Graft and Post–Stem-Cell Infusion
	J.A. Sosman, P. Stiff, S.M. Moss, P. Sorokin, B. Martone, R. Bayer, K. van Besien, S. Devine, W. Stock, D. Peace, Y. Chen, C. Long, D. Gustin, M. Viana, and R. Hoffman
	JCO Feb 1 2001: 634–644. [Abstract] [Full Text] [PDF]
	Prognostic and Predictive Significance of ErbB-2 Breast Tumor Levels Measured by Enzyme Immunoassay
	Serenella Eppenberger-Castori, Willy Kueng, Christopher Benz, Rosmarie Caduff, Zsuzsanna Varga, Fridolin Bannwart, Daniel Fink, Holger Dieterich, Michael Hohl, Heinz Müller, Kaja Paris, Fabrice Schoumacher, and Urs Eppenberger
	JCO Feb 1 2001: 645–656. [Abstract] [Full Text] [PDF]
	Structured Exercise Improves Physical Functioning in Women With Stages I and II Breast Cancer: Results of a Randomized Controlled Trial
	Roanne Segal, William Evans, Darren Johnson, Julie Smith, Sal Colletta, Jane Gayton, Stephanie Woodard, George Wells, and Robert Reid
	JCO Feb 1 2001: 657–665. [Abstract] [Full Text] [PDF]

Genitourinary Cancer
	Radical Cystectomy in the Treatment of Invasive Bladder Cancer: Long-Term Results in 1,054 Patients
	John P. Stein, Gary Lieskovsky, Richard Cote, Susan Groshen, An-Chen Feng, Stuart Boyd, Eila Skinner, Bernard Bochner, Duriayai Thangathurai, Maged Mikhail, Derek Raghavan, and Donald G. Skinner
	JCO Feb 1 2001: 666–675. [Abstract] [Full Text] [PDF]
	Increased Temperature of Malignant Urinary Bladder Tumors In Vivo: The Application of a New Method Based on a Catheter Technique
	C. Stefanadis, C. Chrysochoou, D. Markou, K Petraki, D. B. Panagiotakos, C. Fasoulakis, A. Kyriakidis, C. Papadimitriou, and P. K. Toutouzas
	JCO Feb 1 2001: 676–681. [Abstract] [Full Text] [PDF]
	Role of Postchemotherapy Adjunctive Surgery in the Management of Patients With Nonseminoma Arising From the Mediastinum
	Jacqueline Vuky, Manjit Bains, Jennifer Bacik, Geralyn Higgins, Dean F. Bajorin, Madhu Mazumdar, George J. Bosl, and Robert J. Motzer
	JCO Feb 1 2001: 682–688. [Abstract] [Full Text] [PDF]

Pediatric Oncology
	Expression of the Neurotrophin Receptor TrkB Is Associated With Unfavorable Outcome in Wilms’ Tumor
	Angelika Eggert, Michael A. Grotzer, Naohiko Ikegaki, Huaqing Zhao, Avital Cnaan, Garrett M. Brodeur, and Audrey E. Evans
	JCO Feb 1 2001: 689–696. [Abstract] [Full Text] [PDF]
	Recombinant Urate Oxidase for the Prophylaxis or Treatment of Hyperuricemia in Patients With Leukemia or Lymphoma
	Ching-Hon Pui, Hazem H. Mahmoud, Joseph M. Wiley, Gerald M. Woods, Guy Leverger, Bruce Camitta, Caroline Hastings, Susan M. Blaney, Mary V. Relling, and Gregory H. Reaman
	JCO Feb 1 2001: 697–704. [Abstract] [Full Text] [PDF]

Lung Cancer
	73.6 Gy and Beyond: Hyperfractionated, Accelerated Radiotherapy for Non–Small-Cell Lung Cancer
	Patrick D. Maguire, Lawrence B. Marks, Gregory S. Sibley, James E. Herndon II, Robert W. Clough, Kim L. Light, Maria L. Hernando, Philip A. Antoine, and Mitchell S. Anscher
	JCO Feb 1 2001: 705–711. [Abstract] [Full Text] [PDF]
	Use of Hematopoietic Progenitors in Whole Blood to Support Dose-Dense Chemotherapy: A Randomized Phase II Trial in Small-Cell Lung Cancer Patients
	Penella J. Woll, Nicholas Thatcher, Lynn Lomax, Jackie Hodgetts, S. Ming Lee, Paul A. Burt, Ronald Stout, Tanya Simms, Rowena Davies, and Ruth Pettengell
	JCO Feb 1 2001: 712–719. [Abstract] [Full Text] [PDF]

Hematologic Malignancies
	CD4+ T-Cell Immune Response to Large B-Cell Non-Hodgkin’s Lymphoma Predicts Patient Outcome
	Stephen M. Ansell, Mary Stenson, Thomas M. Habermann, Diane F. Jelinek, and Thomas E. Witzig
	JCO Feb 1 2001: 720–726. [Abstract] [Full Text] [PDF]
	High-Dose Therapy and Autologous Stem-Cell Support for Chemosensitive Transformed Low-Grade Follicular Non-Hodgkin’s Lymphoma: A Case-Matched Study From the European Bone Marrow Transplant Registry
	C. D. Williams, C. N. Harrison, T. A. Lister, A. J. Norton, A. K. Blystad, B. Coiffier, G. Taghipour, N. Schmitz, and A. H. Goldstone
	JCO Feb 1 2001: 727–735. [Abstract] [Full Text] [PDF]
	Results of a Prospective Trial of Mantle Irradiation Alone for Selected Patients With Early-Stage Hodgkin’s Disease
	Kendall H. Backstrand, Andrea K. Ng, Ronald W. Takvorian, Ellen L. Jones, David C. Fisher, Beverly J. Molnar-Griffin, Barbara Silver, Nancy J. Tarbell, and Peter M. Mauch
	JCO Feb 1 2001: 736–741. [Abstract] [Full Text] [PDF]
	Results of Intensive Chemotherapy Followed by Hematopoietic Stem-Cell Rescue in 22 Patients With Refractory or Recurrent Primary CNS Lymphoma or Intraocular Lymphoma
	Carole Soussain, Florence Suzan, Khê Hoang-Xuan, Nathalie Cassoux, Vincent Levy, Nabih Azar, Coralie Belanger, Eddine Achour, Vincent Ribrag, Sophie Gerber, Jean-Yves Delattre, and and Véronique Leblond
	JCO Feb 1 2001: 742–749. [Abstract] [Full Text] [PDF]
	Infusional CHOP Chemotherapy (CVAD) With or Without Chemosensitizers Offers No Advantage Over Standard CHOP Therapy in the Treatment of Lymphoma: A Southwest Oncology Group Study
	Ellen R. Gaynor, Joseph M. Unger, Thomas P. Miller, Thomas M. Grogan, Leonard A. White, Jr, Glenn M. Mills, Stanley P. Balcerzak, Mary Varterasian, Michael LeBlanc, and Richard I. Fisher
	JCO Feb 1 2001: 750–755. [Abstract] [Full Text] [PDF]
	Neutropenic Enterocolitis in Patients With Acute Leukemia: Prognostic Significance of Bowel Wall Thickening Detected by Ultrasonography
	Claudio Cartoni, Francesco Dragoni, Alessandra Micozzi, Edoardo Pescarmona, Sergio Mecarocci, Piero Chirletti, Maria Concetta Petti, Giovanna Meloni, and Franco Mandelli
	JCO Feb 1 2001: 756–761. [Abstract] [Full Text] [PDF]
	Troxacitabine, A Novel Dioxolane Nucleoside Analog, Has Activity in Patients With Advanced Leukemia
	Francis J. Giles, Jorge E. Cortes, Sharyn D. Baker, Deborah A. Thomas, Susan O’Brien, Terry L. Smith, Miloslav Beran, Carol Bivins, Jacques Jolivet, and Hagop M. Kantarjian
	JCO Feb 1 2001: 762–771. [Abstract] [Full Text] [PDF]
	Identification of Prognostic Factors in 61 Patients With Posttransplantation Lymphoproliferative Disorders
	Véronique Leblond, Nathalie Dhedin, Marie-France Mamzer Bruneel, Sylvain Choquet, Olivier Hermine, Raphaël Porcher, Stéphanie Nguyen Quoc, Frédéric Davi, Frédéric Charlotte, Richard Dorent, Benoit Barrou, Jean-Paul Vernant, Martine Raphael, and Vincent Levy
	JCO Feb 1 2001: 772–778. [Abstract] [Full Text] [PDF]
	Clinical Characteristics and Outcome of Patients With Extracutaneous Mycosis Fungoides
	Ellen C. de Coninck, Youn H. Kim, Anna Varghese, and Richard T. Hoppe
	JCO Feb 1 2001: 779–784. [Abstract] [Full Text] [PDF]

Clinical Trials
	Application of a New Multinomial Phase II Stopping Rule Using Response and Early Progression
	S. Dent, B. Zee, J. Dancey, A. Hanauske, J. Wanders, and E. Eisenhauer
	JCO Feb 1 2001: 785–791. [Abstract] [Full Text] [PDF]

Head and Neck Cancer
	Radiation Concurrent With Gemcitabine for Locally Advanced Head and Neck Cancer: A Phase I Trial and Intracellular Drug Incorporation Study
	Avraham Eisbruch, Donna S. Shewach, Carol R. Bradford, James F. Littles, Theodore N. Teknos, Douglass B. Chepeha, Lawrence J. Marentette, Jeffrey E. Terrell, Norman D. Hogikyan, Laura A. Dawson, Susan Urba, Gregory T. Wolf, and Theodore S. Lawrence
	JCO Feb 1 2001: 792–799. [Abstract] [Full Text] [PDF]
	Concurrent Paclitaxel and Radiation in the Treatment of Locally Advanced Head and Neck Cancer
	John B. Sunwoo, Laurie L. Herscher, Glenn S. Kroog, Giovana R. Thomas, Frank G. Ondrey, Dianne C. Duffey, Beth I. Solomon, Carol Boss, Paul S. Albert, Linda McCullugh, Susan Rudy, Chris Muir, Suoping Zhai, William D. Figg, John A. Cook, James B. Mitchell, and Carter Van Waes
	JCO Feb 1 2001: 800–811. [Abstract] [Full Text] [PDF]

Melanoma
	Patient Preferences for Adjuvant Interferon Alfa-2b Treatment
	Kerry L. Kilbridge, Jane C. Weeks, Arthur J. Sober, Frank G. Haluska, Craig L. Slingluff, Michael B. Atkins, Dana E. Sock, John M. Kirkwood, and Robert F. Nease
	JCO Feb 1 2001: 812–823. [Abstract] [Full Text] [PDF]
	Serum S-100B Protein as a Prognostic Marker in Malignant Cutaneous Melanoma
	E. Djureen Mårtenson, L.O. Hansson, B. Nilsson, E. von Schoultz, E. Månsson Brahme, U. Ringborg, and J. Hansson
	JCO Feb 1 2001: 824–831. [Abstract] [Full Text] [PDF]

Phase I and Clinical Pharmacology
	Phase I Study of Infusional Paclitaxel in Combination With the P-Glycoprotein Antagonist PSC 833
	Isagani Chico, Min H. Kang, Raymond Bergan, Jame Abraham, Susan Bakke, Beverly Meadows, Ann Rutt, Rob Robey, Peter Choyke, Maria Merino, Barry Goldspiel, Tom Smith, Seth Steinberg, William D. Figg, Tito Fojo, and Susan Bates
	JCO Feb 1 2001: 832–842. [Abstract] [Full Text] [PDF]
	Phase I Safety and Pharmacokinetic Study of Recombinant Human Anti-Vascular Endothelial Growth Factor in Patients With Advanced Cancer
	M. S. Gordon, K. Margolin, M. Talpaz, G. W. Sledge, Jr, E. Holmgren, R. Benjamin, S. Stalter, S. Shak, and D. C. Adelman
	JCO Feb 1 2001: 843–850. [Abstract] [Full Text] [PDF]
	Phase Ib Trial of Intravenous Recombinant Humanized Monoclonal Antibody to Vascular Endothelial Growth Factor in Combination With Chemotherapy in Patients With Advanced Cancer: Pharmacologic and Long-Term Safety Data
	K. Margolin, M. S. Gordon, E. Holmgren, J. Gaudreault, W. Novotny, G. Fyfe, D. Adelman, S. Stalter, and J. Breed
	JCO Feb 1 2001: 851–856. [Abstract] [Full Text] [PDF]
	Phase I and Pharmacokinetic Study of LU79553, a DNA Intercalating Bisnaphthalimide, in Patients With Solid Malignancies
	Miguel A. Villalona-Calero, Joseph P. Eder, Deborah L. Toppmeyer, Lee F. Allen, Robert Fram, Raja Velagapudi, Michael Myers, Anthony Amato, Kathleen Kagen-Hallet, Betty Razvillas, Donald W. Kufe, Daniel D. Von Hoff, and Eric K. Rowinsky
	JCO Feb 1 2001: 857–869. [Abstract] [Full Text] [PDF]

REVIEW ARTICLES
	How Effective Is Dose-Intensive/Myeloablative Therapy Against Ewing’s Sarcoma/Primitive Neuroectodermal Tumor Metastatic to Bone or Bone Marrow? The Memorial Sloan-Kettering Experience and a Literature Review
	Brian H. Kushner and Paul A. Meyers
	JCO Feb 1 2001: 870–880. [Abstract] [Full Text] [PDF]
	Aromatase Inhibitors in the Treatment and Prevention of Breast Cancer
	Paul E. Goss and Kathrin Strasser
	JCO Feb 1 2001: 881–894. [Abstract] [Full Text] [PDF]
	Insomnia in the Context of Cancer: A Review of a Neglected Problem
	Josée Savard and Charles M. Morin
	JCO Feb 1 2001: 895–908. [Abstract] [Full Text] [PDF]

DIAGNOSIS IN ONCOLOGY

Unusual Presentations of Germ Cell Tumors: Case 1. Recurrent Laryngeal Nerve Palsyin Mediastinal Seminoma

Lisa Horvath, Mathew Bayfield, Anthony Clifford, Dorothy Painter, and Stephen Clarke

JCO Feb 1 2001: 909–911. [Full Text] [PDF]

Unusual Presentations of Germ Cell Tumors: Case 2. Seminoma of the Conus Medullaris

Lisa Horvath, David McDowell, Graham Stevens, Richard Parkinson, Stanley McCarthy, and Michael Boyer

JCO Feb 1 2001: 911–915. [Full Text]

Unusual Presentations of Germ Cell Tumors: Case 3. Nonseminomatous Extragonadal Germ Cell TumorPresenting with Pulmonary Emboli

Sandeep T. Laroia, Debra A. Schell, Robert Koch, and Anil Potti

JCO Feb 1 2001: 915–916. [Full Text]

ART OF ONCOLOGY

A Good Death: Not Just an Abstract Concept

Gail Gazelle

JCO Feb 1 2001: 917–918. [Full Text] [PDF]

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